The story of spontaneously hypertensive rat (SHR): A Review
نویسنده
چکیده
منابع مشابه
Blood pressure QTL that differentiate Dahl salt-sensitive and spontaneously hypertensive rats.
Our purpose was to define quantitative trait loci (QTL) for blood pressure that differ between two widely used hypertensive rat strains, the Dahl salt-sensitive (S) rat and the spontaneously hypertensive rat (SHR). A genome scan was done on an F(2) (S x SHR) population fed 8% NaCl for 4 wk. Three blood pressure QTL were detected, one on each of rat chromosomes (chr) 3, 8, and 9. For the chr 3 Q...
متن کاملDifferent susceptibilities to cerebral infarction in spontaneously hypertensive (SHR) and normotensive Sprague-Dawley rats.
Rapid occlusion of the middle cerebral artery (MCA) was undertaken in 5-6 week old rats to determine whether or not the young spontaneously hypertensive rat (SHR) or the normotensive Sprague-Dawley rat (SD) is protected against cerebral infarction by collateral circulation. Rats were killed 3 days after MCA occlusion and administration of Evans blue. As compared to SD, the SHR had elevated bloo...
متن کاملOxidative Damage in Cardiac Tissue from Normotensive and Spontaneously Hypertensive Rats: Effect of Ageing
The spontaneously hypertensive rat (SHR) is a laboratory model of naturally developing hypertension and heart failure that appears to be similar in many aspects to essential hypertension in humans (Trippodo & Frohlich, 1981). Systolic blood pressure in SHR rapidly increases during 5 to 10 weeks of age and develops cardiac hypertrophy between 9 and 12 weeks of age (Shimamoto et al., 1982). Incre...
متن کاملMorphometric analysis of cardiac hypertrophy during development, maturation, and senescence in spontaneously hypertensive rats.
Hypertrophy of the mammalian heart, regardless of the initiating event, results in architectural remodeling of ventricular components that maintain structural and functional characteristics of this organ. Ventricular components that vary their morphology and morphometry in a hypertrophic state are the muscle cells, connective tissue elements, vasculature, or a combination of some or all of the ...
متن کاملMyogenic and structural properties of cerebral arteries from the stroke-prone spontaneously hypertensive rat.
The aims of the study were to compare the myogenic and structural properties of middle cerebral arteries (MCAs) from the stroke-prone spontaneously hypertensive rat (SHRSP) with MCAs from the spontaneously hypertensive rat (SHR) before stroke development in SHRSP. Rats were fed a "Japanese" diet (low-protein rat chow and 1% NaCl in drinking water) for 8 wk, and cerebral arteries were studied in...
متن کامل